C/EBPβ–VCAM1 axis in Kupffer cells promotes hepatic inflammation in MASLD
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide, but its pathogenesis remains elusive. In this study, we investigated the critical role of CCAAT/enhancer binding protein β (C/EBPβ) in Kupffer cells and its implications in MASLD pathogenesis. We found that an increased C/EBPβ level in Kupffer cells promotes hepatic inflammation in MASLD by upregulating VCAM1 expression. Our findings provide valuable insights into the molecular mechanisms driving MASLD and propose a potential novel therapeutic target to mitigate hepatic inflammation in MASLD.
Authors
- Rui Xue (ORCID: https://orcid.org/0000-0002-5710-0091)
- Mingxi Liu (ORCID: https://orcid.org/0000-0001-6499-7899)
- Shuang‐Zhe Lin (ORCID: https://orcid.org/0000-0002-5695-8694)
- Yang Xie (ORCID: https://orcid.org/0000-0002-9421-301X)
- Yuqing Cheng (ORCID: https://orcid.org/0009-0003-3634-1202)
- Yuanwen Chen (ORCID: https://orcid.org/0000-0003-4210-007X)
- Yangang Su (ORCID: https://orcid.org/0000-0003-4801-8595)
- Jian‐Gao Fan (ORCID: https://orcid.org/0000-0002-8618-6402)
Institutions
- Shanghai Jiao Tong University (CN)
- Nantong University (CN)
- Fudan University (CN)
- XinHua Hospital (CN)
- Shanghai Institute of Nutrition and Health (CN)
- Huadong Hospital (CN)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101418
- Citations
- 6
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China
- Shanghai Jiao Tong University
- National Science and Technology Major Project
- School of Medicine, Shanghai Jiao Tong University
- National Major Science and Technology Projects of China