NIR-II-responsive photothermal microneedle patch loaded with myricetin nanodrugs for the treatment of drug-resistant bacteria-infected wounds

Drug-resistant bacterium-infected wounds pose a serious threat to human health and constitute one of the major causes of death in the clinic. It is necessary to develop a novel treatment platform with remarkable anti-infective properties and wound-healing ability. Herein, a myricetin nanodrug-loaded microneedle patch (HMY-HA@SF-MNs) with a photothermal therapeutic effect and wound healing capacity was designed and fabricated for the treatment of drug-resistant bacterium-infected wounds. The nanodrug is synthesized by self-assembly of myricetin, Mg 2+ and humic acid, which results in outstanding anti-inflammatory and antioxidant effects and thus further promotes cell proliferation. In addition, the nanodrug-loaded microneedle patch shows strong photothermic conversion efficiency, and its temperature can increase to 60.3 ​°C under irradiation with a 1064 ​nm near-infrared (NIR) laser. The microneedle patch had high biological safety, demonstrated remarkable reactive oxygen species (ROS) scavenging activity and had a significant therapeutic effect on Methicillin-resistant Staphylococcus aureus -infected wounds under NIR irradiation. The myricetin nanodrug-based microneedle patch may serve as an efficient route for clinical application in the treatment of drug-resistant bacterium-infected wounds. • A NIR-II-responsive photothermal platform has been designed for treating drug-resistant bacterial infections in wounds, integrating anti-inflammatory, antibacterial, and enhanced cell proliferation properties. • This approach overcomes the limitations of the low solubility and poor permeability of myricetin in its application.