<scp>G3BP1</scp> , a stress granule core protein, ameliorates metabolic dysfunction‐associated fatty liver disease by attenuating hepatocyte lipid deposition
This study reveals for the first time a protective role for SGs in MAFLD. Specifically, knocking down the core G3BP1 molecule in SGs aggravated the progression of fatty acid-induced MAFLD through a mechanism that may involve the nuclear entry of APOC3. These findings provide a new therapeutic direction for MAFLD.
Authors
- Meijuan Dong (ORCID: https://orcid.org/0000-0001-6173-5156)
- Dezhen Liu
- Yue Xu (ORCID: https://orcid.org/0000-0002-5160-6251)
- Xingjing Liu (ORCID: https://orcid.org/0000-0002-7996-9775)
- Huimei Yu (ORCID: https://orcid.org/0000-0001-9516-2800)
- Yiming Li
- Qi Yuan (ORCID: https://orcid.org/0000-0002-1160-6118)
- Tongtong Hu
- Yu He (ORCID: https://orcid.org/0000-0002-8960-7081)
- Li Mao
Institutions
- Xuzhou Medical College (CN)
- Huaian First People’s Hospital (CN)
- Second People’s Hospital of Huai’an (CN)
- Yangzhou University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1111/dom.16302
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- National Natural Science Foundation of China