MUCOADHESIVE DRUG DELIVERY SYSTEM: FORMULATION AND EVALUATION MODELS

Mucoadhesion, the phenomenon wherein materials, adhere for prolonged durations through interfacial forces, presents a compelling approach to address the challenges of traditional drug delivery systems, such as first-pass metabolism and the localized delivery of biomolecules, including proteins, peptides, and oligonucleotides. Mucoadhesion has significant potential for the delivery of many substances through multiple routes of administration, including ophthalmic, nasal, vaginal, and buccal. Moreover, mucoadhesion facilitates sustained local or systemic medication efficacy. This review study aims to examine the possible applications of mucoadhesion, the mechanisms of mucoadhesion, and various recent advances in formulation-based approaches for mucoadhesive drug delivery. Furthermore, focusing on the new models for in vitro, in vivo, and ex vivo studies for mucoadhesive drug delivery systems. The development of more effective and patient-friendly drug delivery methods that address issues with first-pass metabolism and low drug solubility is made possible by these findings.