Haematological and Biochemical Parameters in COVID-19 Patients Attending a Tertiary Care Hospital: A Retrospective Study

Introduction: The SARS-CoV-2 RNA virus, which causes COVID-19disease, rapidly spread to the entire world. COVID-19 mainly involves therespiratory tract, now found to be linked with systemic diseases due tomultiple organ involvement. Limited data are available regarding the effectof COVID-19 on various haematological and biochemical parameters.Materials and Methods: A retrospective cross-sectional study was carriedout on 400 cases from March 2021 to August 2021. Two hundredCOVID-19 RT-PCR confirmed cases formed the study group and 200subjects who tested negative were included in the controls to studyvarious haematological and biochemical parameters.Results: Thrombocytopenia was significantly noticed in cases as comparedto controls (65.3% and 34.7%, respectively), with cases 2.45 times morelikely to be thrombocytopenic (p < 0.01). Leucopenia was 1.79 timeshigher in cases (62.8%) in comparison to controls (37.2%). Moreover,positive cases were 1.35 times more anaemic than control. The meanindices for serum bilirubin (p = 0.020), serum creatinine (p < 0.001),alanine transaminase (p = 0.081), blood urea (p < 0.001), procalcitonin(p < 0.001) and c-reactive protein (p < 0.001) were significantly raisedin cases in comparison to controls.Conclusion: Thrombocytopenia, leucopenia along with raised serumbilirubin, creatinine, ALT, AST, CRP and procalcitonin may be beneficialin the diagnosis of COVID-19. Meticulous assessment and correlation ofhaematological and biochemical parameters at the time of admission andsimultaneously during the disease course will be helpful to physiciansin formulating individualised treatment along with decision-makingregarding requiring intensive care to those in need. How to cite this article:Omhare A, Singh S, Yadav S K, Yadav K, ChaudharyS, Mishra K L. Haematological and BiochemicalParameters in COVID-19 Patients Attending aTertiary Care Hospital: A Retrospective Study. JCommun Dis. 2025;57(1):115-120. DOI: https://doi.org/10.24321/0019.5138.202515