PDE7 as a Precision Target: Bridging Disease Modulation and Potential PET Imaging for Translational Medicine

Phosphodiesterase 7 (PDE7) regulates cAMP-PKA signaling and plays a crucial role in immune function, neuroprotection, and inflammation. Dysregulated PDE7 activity is linked to neurodegenerative, autoimmune, and metabolic disorders, making it a promising therapeutic target. Recent advancements in PDE7 inhibitors, particularly pyrimidinone-based compounds, have shown high selectivity and potent biological effects. Beyond therapeutics, radiolabeled PDE7 inhibitors offer potential for PET imaging, enabling noninvasive disease monitoring and treatment assessment.