Metachronous colorectal cancer risks after extended or segmental resection in <i>MLH1</i>, <i>MSH2</i>, and <i>MSH6</i> Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database
This first prospective observational study evaluates the impact of extended versus segmental colorectal surgery on the risk of metachronous colorectal cancer (CRC) in patients with Lynch syndrome, analyzing data from the Prospective Lynch Syndrome Database version 5. Extended resection significantly reduced the risk of metachronous CRC in path_MLH1, path_MSH2, and path_MSH6 carriers compared to segmental resection.
Authors
- Saskia Haupt (ORCID: https://orcid.org/0000-0001-7537-9439)
- Lior H. Katz (ORCID: https://orcid.org/0000-0003-2885-7279)
- А. Н. Петров (ORCID: https://orcid.org/0000-0002-0137-486X)
- Avni Jain (ORCID: https://orcid.org/0000-0002-7858-3272)
- M Bohorquez
- Emma J. Crosbie (ORCID: https://orcid.org/0000-0003-0284-8630)
- Kristina Zalevskaja
- Claudia Perne (ORCID: https://orcid.org/0000-0001-6131-2065)
- Áine Stakelum (ORCID: https://orcid.org/0000-0002-1593-758X)
- Reinhard Büttner (ORCID: https://orcid.org/0000-0001-8806-4786)
- Magnus von Knebel Doeberitz (ORCID: https://orcid.org/0000-0002-0498-6781)
- Bernard Rossi (ORCID: https://orcid.org/0000-0003-2614-4910)
- D. C. Winter (ORCID: https://orcid.org/0000-0002-9559-6438)
- Karin Alvarez-Valenzuela
- Jürgen Weitz (ORCID: https://orcid.org/0000-0002-5760-6391)
- Mev Dominguez–Valentin (ORCID: https://orcid.org/0000-0001-7856-0057)
- Gabriela Möslein (ORCID: https://orcid.org/0000-0002-0639-8350)
- Joaquin Castillo-Iturra
- Annika Lindblom (ORCID: https://orcid.org/0000-0001-7675-7569)
- Douglas Tjandra (ORCID: https://orcid.org/0000-0002-2236-5225)
- Stefan Aretz (ORCID: https://orcid.org/0000-0002-5228-1890)
- Núria Dueñas (ORCID: https://orcid.org/0000-0001-6624-3265)
- John L. Hopper (ORCID: https://orcid.org/0000-0002-8567-173X)
- Toni T. Seppälä (ORCID: https://orcid.org/0000-0002-4940-3498)
- Walter Pavicic (ORCID: https://orcid.org/0000-0001-7840-4943)
- Markus Loeffler (ORCID: https://orcid.org/0000-0002-0424-9933)
- Dirce Maria Carraro (ORCID: https://orcid.org/0000-0001-5667-1418)
- Karl Heinimann (ORCID: https://orcid.org/0000-0002-7577-0523)
- Robert Hüneburg (ORCID: https://orcid.org/0000-0001-9957-8299)
- Jane C. Figueiredo (ORCID: https://orcid.org/0000-0002-2452-3194)
- Laura Renkonen‐Sinisalo (ORCID: https://orcid.org/0000-0002-3122-5312)
- Noralane M. Lindor (ORCID: https://orcid.org/0000-0001-6129-3490)
- Patricia Esperón
- John Burn (ORCID: https://orcid.org/0000-0002-9823-2322)
- Nils Rahner
- Steven Gallinger
- K Green
- Giulia Martina Cavestro (ORCID: https://orcid.org/0000-0003-1947-9368)
- Gabriel Capellá (ORCID: https://orcid.org/0000-0002-4669-7320)
- Lucio Bertario (ORCID: https://orcid.org/0000-0001-5653-1431)
- Francisco Lopez-Koestner
- Julian R. Sampson (ORCID: https://orcid.org/0000-0002-2902-2348)
- Norma Rossi (ORCID: https://orcid.org/0000-0001-5825-5047)
- Elizabeth Half (ORCID: https://orcid.org/0000-0002-4508-8670)
- Zohar Levi (ORCID: https://orcid.org/0000-0003-2456-8891)
- Silke Redler (ORCID: https://orcid.org/0000-0002-0991-252X)
- Revital Kariv
- Anna Lepistö (ORCID: https://orcid.org/0000-0002-5866-4059)
- Attila Zaránd
- Francesc Balaguer (ORCID: https://orcid.org/0000-0002-0206-0539)
- E Vainer
- Evelin Schröck (ORCID: https://orcid.org/0000-0002-3377-1704)
- Guy Rosner (ORCID: https://orcid.org/0000-0003-1044-4935)
- Robert W. Haile (ORCID: https://orcid.org/0000-0001-6902-1836)
- Lars Joachim Lindberg (ORCID: https://orcid.org/0000-0002-1764-1571)
- Leticia Moreira (ORCID: https://orcid.org/0000-0002-4518-8591)
- Luigi Laghi (ORCID: https://orcid.org/0000-0003-4187-1059)
- Yael Goldberg (ORCID: https://orcid.org/0000-0002-9855-9472)
- Polly A. Newcomb (ORCID: https://orcid.org/0000-0001-8786-0043)
- Kevin John Monahan (ORCID: https://orcid.org/0000-0002-7918-4003)
- Loı̈c Le Marchand (ORCID: https://orcid.org/0000-0001-5013-980X)
- Harsh Sheth (ORCID: https://orcid.org/0000-0001-9626-0971)
- Giovana Tardin Torrezan (ORCID: https://orcid.org/0000-0002-8659-5329)
- Huw Thomas (ORCID: https://orcid.org/0000-0002-6465-229X)
- Elke Holinski‐Feder (ORCID: https://orcid.org/0000-0002-5172-2818)
- Leonardo Saul Lino-Silva (ORCID: https://orcid.org/0000-0002-7394-5123)
- Vincent Heuveline (ORCID: https://orcid.org/0000-0002-2217-7558)
- Joan Brunet (ORCID: https://orcid.org/0000-0003-1945-3512)
- Maartje Nielsen (ORCID: https://orcid.org/0000-0002-5351-1870)
- Daniel D. Buchanan (ORCID: https://orcid.org/0000-0003-2225-6675)
- Nathan Gluck (ORCID: https://orcid.org/0000-0001-5503-488X)
- Marc S. Greenblatt (ORCID: https://orcid.org/0000-0002-1729-8355)
- J-P Plazzer
- Karoline Horisberger (ORCID: https://orcid.org/0000-0001-6143-6607)
- Jukka‐Pekka Mecklin (ORCID: https://orcid.org/0000-0003-4895-2249)
- Aung Ko Win (ORCID: https://orcid.org/0000-0002-2794-5261)
- Inge Bernstein (ORCID: https://orcid.org/0000-0003-4095-432X)
- Naim Abu‐Freha (ORCID: https://orcid.org/0000-0002-4844-3308)
- Robert Fruscio (ORCID: https://orcid.org/0000-0001-5688-2194)
- Rory Kennelly (ORCID: https://orcid.org/0000-0003-0325-5810)
- Finlay Macrae (ORCID: https://orcid.org/0000-0003-4035-9678)
- Juan Ruiz‐Bañobre
- Ivana do Nascimento
- Ismail Gögenür (ORCID: https://orcid.org/0000-0002-3753-268X)
- Lone Sunde (ORCID: https://orcid.org/0000-0002-8479-165X)
- Verena Steinke‐Lange (ORCID: https://orcid.org/0000-0001-8491-3234)
- Ingrid Winship (ORCID: https://orcid.org/0000-0001-8535-6003)
- Sanne W. ten Broeke (ORCID: https://orcid.org/0000-0001-6280-0087)
- Bernardo Bonanni (ORCID: https://orcid.org/0000-0003-3589-2128)
- Rolf H. Sijmons (ORCID: https://orcid.org/0000-0001-8446-2779)
- Marta Pineda (ORCID: https://orcid.org/0000-0002-5403-5845)
- Tadeusz Dębniak (ORCID: https://orcid.org/0000-0002-3506-8932)
- Kirsi Pylvänäinen (ORCID: https://orcid.org/0000-0003-4399-9283)
- Deepak Vangala (ORCID: https://orcid.org/0000-0002-4175-5683)
- Eivind J. Hovig (ORCID: https://orcid.org/0000-0002-9103-1077)
- Ido Laish (ORCID: https://orcid.org/0000-0003-0324-9998)
- Adriana Della Valle (ORCID: https://orcid.org/0000-0003-3802-6970)
- Thiago Bassaneze
- D. Gareth Evans (ORCID: https://orcid.org/0000-0002-8482-5784)
- Claire Martin (ORCID: https://orcid.org/0000-0001-7755-3613)
- Carlos Vaccaro (ORCID: https://orcid.org/0000-0002-1299-5864)
- Pål Møller (ORCID: https://orcid.org/0000-0001-8211-8237)
- Stephen N. Thibodeau (ORCID: https://orcid.org/0000-0003-0078-8558)
- Mark A. Jenkins (ORCID: https://orcid.org/0000-0002-8964-6160)
- Wolff Schmiegel (ORCID: https://orcid.org/0000-0002-1783-9764)
- James Hill (ORCID: https://orcid.org/0000-0003-3178-4402)
- Ariadna Sánchez (ORCID: https://orcid.org/0000-0003-0409-1328)
- Miriam Mints
- Mitul Shah
- F Neffa
- P Shah
- Fiona Lalloo
- Layaly Ayoub Silva
- K. Ojala
- Maria Grazia Tibiletti
Institutions
- Moisio Hospital (FI)
Publication Details
- Journal
- British journal of surgery
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1093/bjs/znaf061
- Citations
- 5
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 7.36
Funders
- Helsingin Yliopisto
- Victorian Cancer Agency
- Central Manchester University Hospitals NHS Foundation Trust
- Deutsches Krebsforschungszentrum
- Health and Care Research Wales
- Centres de Recerca de Catalunya
- Parc Geneteg Cymru
- National Institute for Health and Care Research
- Cardiff University
- Cancer Australia
- Rijksuniversiteit Groningen
- University of Melbourne
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Academy of Finland
- Generalitat de Catalunya
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Technische Universität Dresden
- Ministerio de Economía y Competitividad
- University of Toronto
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Jane ja Aatos Erkon Säätiö
- Karolinska Institutet
- KWF Kankerbestrijding
- Università degli Studi di Parma
- Ministerio de Ciencia e Innovación
- Universitair Medisch Centrum Groningen
- Jyväskylän Yliopisto
- Universitetet i Oslo
- Deutsche Krebshilfe
- Sigrid Juséliuksen Säätiö
- Rheinische Friedrich-Wilhelms-Universität Bonn
- Maag Lever Darm Stichting
- Tays
- Syöpäsäätiö
- Deutschen Konsortium für Translationale Krebsforschung
- Universitätsklinikum Köln
- Centro de Investigación Biomédica en Red de Cáncer
- Relander Foundation
- Humanitas Research Hospital
- Instituto de Salud Carlos III
- Etelä-Savon Rahasto
- European Regional Development Fund
- Stanford Cancer Institute