HD6277 Suppresses Muscle Atrophy by Promoting Myogenic Factors and Inhibiting Proteolysis in Aged Mice
HD6277 can increase myogenic factors and reduce E3 ligase-mediated proteolysis to inhibit muscle atrophy in aged mice. Our results suggest that GPR40 agonists may have potential as therapeutic agents for sarcopenia.
Authors
- Minjeong Park (ORCID: https://orcid.org/0000-0002-2204-2901)
- Sei Hyun Baik (ORCID: https://orcid.org/0000-0002-0665-9266)
- Sooyeon Jang
- Hwan‐Jin Hwang (ORCID: https://orcid.org/0000-0002-3214-3503)
- Kyung Mook Choi (ORCID: https://orcid.org/0000-0001-6175-0225)
- Hye Jin Yoo (ORCID: https://orcid.org/0000-0003-0600-0266)
- Eyun Song
- SukHwan Yun
- Joo Won Kim (ORCID: https://orcid.org/0000-0002-3173-7270)
- Ahreum Jang
Institutions
- Korea University (KR)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/jcsm.13805
- Citations
- 2
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Research Foundation of Korea