Impact of Fatigue on Subjective and Objective Cognitive Functions in Persons with Post-COVID-19 Condition
Post-COVID-19 condition (PCC) is a serious debilitating condition that develops after the resolution of an acute infection of severe acute respiratory syndrome-associated coronavirus 2. Some commonly reported symptoms include fatigue and cognitive deficits. Multiple lines of evidence have indicated fatigue to be associated with cognitive deficits in the general population. Herein, we perform a secondary analysis of the effects of fatigue on subjective and objective cognition in persons with PCC using a generalized linear model. In this study, fatigue was measured using the Fatigue Severity Scale (FSS) and cognition was measured using the Digit-Symbol Substitution Test (DSST) and the Trails Making Test parts A and B (TMT-A/B). FSS had a statistically significant negative correlation with DSST and TMT-A/B scores. Fatigue serves as a possible target for the development of PCC therapeutics. Fatigue and cognition correlates should be further investigated for underlying neurobiological substrates in persons with PCC.
Authors
- Angela T.H. Kwan (ORCID: https://orcid.org/0000-0003-4013-1112)
- Mehala Subramaniapillai (ORCID: https://orcid.org/0000-0002-6917-3984)
- Hartej Gill (ORCID: https://orcid.org/0000-0002-3568-8816)
- Rodrigo B. Mansur (ORCID: https://orcid.org/0000-0002-3968-3297)
- Gia Han Le (ORCID: https://orcid.org/0000-0001-6457-0086)
- Shakila Meshkat (ORCID: https://orcid.org/0000-0002-7010-1785)
- Danica E. Johnson (ORCID: https://orcid.org/0000-0003-2000-7691)
- Joshua D. Rosenblat (ORCID: https://orcid.org/0000-0002-4773-2191)
- Lee Phan (ORCID: https://orcid.org/0000-0001-8183-0265)
- Roger Ho (ORCID: https://orcid.org/0000-0001-9629-4493)
- Sebastian Badulescu
- Roger S. McIntyre (ORCID: https://orcid.org/0000-0003-4733-2523)
- Kayla M. Teopiz (ORCID: https://orcid.org/0000-0001-8429-6563)
- Taeho Greg Rhee (ORCID: https://orcid.org/0000-0003-4961-3361)
- Felicia Ceban (ORCID: https://orcid.org/0000-0001-6815-7248)
- Ziji Guo
- Donovan A. Dev (ORCID: https://orcid.org/0009-0000-1412-0554)
- Sabrina Wong (ORCID: https://orcid.org/0009-0002-0928-3433)
- Joshua D. Di Vincenzo
Institutions
- University College Dublin (IE)
- University of Connecticut (US)
- University of Ottawa (CA)
- National University of Singapore (SG)
- University of Toronto (CA)
- Yale University (US)
- Brain and Cognition Discovery Foundation (CA)
- McMaster University (CA)
Publication Details
- Journal
- Clinical Nursing Research
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1177/10547738251329412
- Citations
- 1
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- H. Lundbeck A/S