Unveiling the molecular landscape and clinically relevant molecular heterogeneity of mucosal melanoma of the head and neck region
MM-H&N shows a significant percentage of WT cases and a limited number of targetable mutations, predominantly involving BRAF/RAS mutations, the latter of which are associated with mucosal lentiginous histology. A subset of patients with consecutive samples demonstrates discordant molecular results, indicating that NGS of all samples may be necessary to determine the most appropriate therapeutic approach.
Authors
- Stephan Ihrler (ORCID: https://orcid.org/0000-0002-6183-0249)
- Achille Tarsitano (ORCID: https://orcid.org/0000-0002-5815-7591)
- Antonio De Leo (ORCID: https://orcid.org/0000-0002-3761-5135)
- Michelangelo Fiorentino (ORCID: https://orcid.org/0000-0002-1749-150X)
- Daniela Massi (ORCID: https://orcid.org/0000-0002-5688-5923)
- Giulia Querzoli (ORCID: https://orcid.org/0000-0002-6944-6508)
- Costantino Ricci (ORCID: https://orcid.org/0000-0001-7254-4195)
- Maria Pia Foschini (ORCID: https://orcid.org/0000-0001-7079-7260)
- Ernesto Pasquini (ORCID: https://orcid.org/0000-0001-8480-0387)
- Chiara Baldovini (ORCID: https://orcid.org/0000-0002-1499-4654)
- Dario de Biase (ORCID: https://orcid.org/0000-0002-0609-8817)
- Thais Maloberti (ORCID: https://orcid.org/0000-0002-8306-4653)
- Luca Amorosa (ORCID: https://orcid.org/0000-0002-5400-466X)
- Anna Maria Baietti (ORCID: https://orcid.org/0000-0001-7563-6730)
- Tiziana Balbi (ORCID: https://orcid.org/0000-0002-9801-7542)
- Gabriele Molteni (ORCID: https://orcid.org/0000-0001-7764-2122)
- Giovanni Tallini (ORCID: https://orcid.org/0000-0003-0113-6682)
- Barbara Corti (ORCID: https://orcid.org/0000-0001-6555-6227)
- Maria Vittoria Altavilla
- Francesca Ambrosi (ORCID: https://orcid.org/0000-0001-9046-1115)
- Antonia D’Errico (ORCID: https://orcid.org/0000-0002-6120-7692)
Institutions
- Azienda USL di Bologna (IT)
- Ospedale Bellaria (IT)
- University of Florence (IT)
- New York University (US)
- Ludwig-Maximilians-Universität München (DE)
- University of Bologna (IT)
Publication Details
- Journal
- Histopathology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1111/his.15456
- Citations
- 4
- Primary Topic
- Cutaneous Melanoma Detection and Management
- Type
- article
- Field-Weighted Citation Impact
- 4.18