Neutrophil-to-lymphocyte ratio-based prognostic score can predict outcomes in patients with advanced non-small cell lung cancer treated with immunotherapy plus chemotherapy
The noninvasive NF score, combining NLR > 3.3 and FIB > 3.196, was superior to PD-L1 estimated from tumor tissue in predicting the efficacy and prognosis of first-line ICI plus chemotherapy in advanced NSCLC patients. The noninvasive NTP score, combining NLR > 3.53 and TKI-PFS > 12 months, is a valuable tool for predicting OS and PFS in advanced NSCLC patients with targetable oncogenic driver alterations receiving second- or post-line ICI combination therapy.
Authors
- Zhe Wu (ORCID: https://orcid.org/0000-0003-2135-6420)
- Wangjun Liao (ORCID: https://orcid.org/0000-0002-1364-8442)
- Hao Lu (ORCID: https://orcid.org/0000-0002-0322-4400)
- Jiani Wu (ORCID: https://orcid.org/0000-0001-7940-4179)
- Huiying Sun (ORCID: https://orcid.org/0000-0002-1584-4949)
- Yuanyuan Wang (ORCID: https://orcid.org/0000-0001-9472-8606)
- Shan Liao (ORCID: https://orcid.org/0000-0002-2243-9941)
- Jianhua Wu (ORCID: https://orcid.org/0000-0003-4142-8903)
- Jingle Xi
Institutions
- Southern Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1186/s12885-025-13811-y
- Citations
- 8
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 8.36
Funders
- Wu Jieping Medical Foundation