Discovery of Pyrroloquinazoline-1,3-diamines as Dual-functionInsecticide Candidates Targeting β-N-acetyl-D-hexosaminidase
PQDs exhibited significant inhibitory activity against OfHex1 and demonstrated substantial insecticidal and fungicidal potency, positioning PQDs as promising candidates for the development of dual-function insecticide candidates.
Authors
- Dengtuo Wang
- Han Zhou (ORCID: https://orcid.org/0000-0002-9538-1680)
- Ke Tang
- Ying‐Qian Liu (ORCID: https://orcid.org/0000-0001-5040-2516)
- Huijie Xie
- Tian Liu (ORCID: https://orcid.org/0000-0001-9768-5496)
- Zhijun Zhang (ORCID: https://orcid.org/0000-0003-3055-3426)
- Xi Jiang (ORCID: https://orcid.org/0000-0003-0103-992X)
Institutions
- Dalian University of Technology (CN)
- Dalian University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2025-04-11
- DOI
- https://doi.org/10.2174/0109298673359016250316122007
- Primary Topic
- Studies on Chitinases and Chitosanases
- Type
- article
- Field-Weighted Citation Impact
- 0.00