The Application of Alfentanil in Anesthesia for Painless Gastrointestinal Endoscopy

阿芬太尼是一种作用于μ受体的新型芬太尼衍生物，为短效强阿片类镇痛药。由于其起效快、作用时间短、无明显药物蓄积，对呼吸和循环的抑制小，不良反应少，安全系数大等特点，目前被广泛应用于无痛胃肠镜检查中。本文结合国内外文献和阿芬太尼的临床药理特性、临床应用优势，给药方案，常用药物组合等方面的研究进展进行综述，旨在优化无痛胃肠镜检查中的麻醉用药方案，为阿芬太尼在临床上的使用提供理论依据。Alfentanil is a new type of fentanyl derivative acting on the μ receptor and is a short-acting and potent opioid analgesic. Due to its characteristics such as rapid onset, short duration of action, no obvious drug accumulation, little inhibition of respiration and circulation, few adverse reactions, and a large safety factor, it is currently widely used in painless gastrointestinal endoscopy. This article reviews the research progress in aspects such as the clinical pharmacological properties, clinical application advantages, administration regimens, and commonly used drug combinations of alfentanil, combined with domestic and foreign literature. It aims to optimize the anesthesia drug regimens for painless gastrointestinal endoscopy and provide a theoretical basis for the clinical use of alfentanil.