Exploring the Potential of Dolutegravir in Alzheimer's Disease Treatment: Insights from Network Pharmacology and In Silico Docking Studies
The findings indicated that dolutegravir holds significant potential in modulating key pathways involved in Alzheimer's disease pathogenesis. These results provide a strong foundation for further investigations into the therapeutic efficacy and safety of dolutegravir in the treatment of Alzheimer's disease. The use of drug repurposing strategies, leveraging Dolutegravir's established pharmacological profile, offers a promising route for accelerated therapeutic development in AD.
Authors
- Ravindra Wavhale (ORCID: https://orcid.org/0000-0003-1614-9742)
- Ritesh Bhole (ORCID: https://orcid.org/0000-0003-4088-7470)
- Karishma Rathi (ORCID: https://orcid.org/0000-0002-6407-6739)
- Vaishali Undale (ORCID: https://orcid.org/0000-0003-3837-7471)
- Pawan N. Karwa
- Nikhil S. Sakle (ORCID: https://orcid.org/0000-0003-2614-1920)
Institutions
- Dr. D. Y. Patil Medical College, Hospital and Research Centre (IN)
Publication Details
- Journal
- Central Nervous System Agents in Medicinal Chemistry
- Published
- 2025-04-15
- DOI
- https://doi.org/10.2174/0118715249350698250317041551
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00