Cold atmospheric plasma drives USP49/HDAC3 axis mediated ferroptosis as a novel therapeutic strategy in endometrial cancer via reinforcing lactylation dependent p53 expression
Our findings illustrate the suppressive effect of CAP treatment on endometrial cancer and uncover a novel regulatory mechanism mediated by CAP. Specifically, CAP modulates the ferroptosis pathway through the HDAC3/H3K18la/p53 axis, presenting a novel therapeutic approach for endometrial cancer treatment.
Authors
- Junhu Wan (ORCID: https://orcid.org/0009-0008-3869-7153)
- Baojin Wang
- Lindong Zhang (ORCID: https://orcid.org/0000-0002-5024-595X)
- Lili Huang (ORCID: https://orcid.org/0000-0003-2925-1375)
- Hongyan Zhang (ORCID: https://orcid.org/0000-0001-6424-3261)
- Zhimin Li (ORCID: https://orcid.org/0000-0003-0972-952X)
- Hongyang Liu
- Jinlin Liu (ORCID: https://orcid.org/0000-0003-0502-4813)
- Jinyang Wang (ORCID: https://orcid.org/0000-0002-2517-7473)
- Ruonan Ma (ORCID: https://orcid.org/0000-0002-4393-380X)
- Youming Chen (ORCID: https://orcid.org/0000-0002-9599-5850)
- Zidi Zhang
Institutions
- Zhengzhou University (CN)
- Shangqiu First People's Hospital (CN)
- Third Affiliated Hospital of Zhengzhou University (CN)
- Shandong Maternal and Child Health Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1186/s12967-025-06449-8
- Citations
- 6
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 9.11
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Henan Province