Report of two rare cases of plasma cell granuloma of the gingiva

Plasma cell granuloma is a rare benign, occasionally aggressive lesion with an unclear etiopathogenesis characterized by plasma cell infiltration. It occurs mainly in the lungs but can also affect the liver, kidneys, brain, and heart. Its occurrence in the oral cavity is rare. In this study, we report two rare cases of plasma cell granuloma involving the maxillary gingiva in a middle-aged male patient and a pregnant woman. In both cases, the lesion appeared red and bleeding. Following excisional biopsy, the specimens were subjected to histopathological analysis and immunohistochemical confirmation, leading to a diagnosis of plasma cell granuloma. Both patients are under monitoring and show no signs of recurrence. The authors also discuss plasma cell granuloma’s clinical, histopathological, and immunohistochemical features. Histopathological examination and complementary immunohistochemistry are crucial for its correct diagnosis. Despite its benign behavior, plasma cell granuloma’s local aggressiveness, rarity in the oral cavity, and similarity with other benign and malignant lesions of the gingiva make its diagnosis difficult.