Chemical and Spectroscopic Characterization of Novel Dexamethasone/Zn Complex as a Potent Antioxidant and Antibacterial Agent

Background: Dexamethasone (DX) is a glucocorticoid drug, its side effects, which include oxidative stress, despite being used to treat inflammatory diseases, Therefore, the primary goal of the study is to evaluate the new DX/Zn drug complex’s potent capacities with an increase in its antioxidant and antibacterial activities. Methods: The DX/Zn novel complex was synthesized and characterized by means of magnetic susceptibility, SEM, TEM, elemental analysis and spectroscopic techniques (IR, 1HNMR, UV and X-ray diffraction). Antioxidant activities were performed via a lot of invitro antioxidant assays (ORAC, ABTS and Metal chelation), antibacterial actions against B. subtilis and E. coli. Result: DX is coordinated toward Zn ion as a monodentate ligand through the oxygen of (C=O).DX/Zn induced antioxidant activities via different antioxidant tests, it exhibits strong antibacterial properties against the bacterial strains B. subtilis and E. coli. Novel DX/Zn novel complex is an effective antioxidant and antibacterial agent.