Leveraging Diverse Cell-Death Patterns to Decipher the Interactive Relation of Unfavorable Outcome and Tumor Microenvironment in Breast Cancer
Our study provided a comprehensive landscape of the cancer survival difference and related PCD-TME interaction axis and highlighted that high-apoptosis/pyroptosis states caused favorable prognosis, underlying mechanisms closely related with the TME where anti-tumor immunity would be beneficial for patient prognosis. These findings highlighted the model's potential for risk stratification in BC.
Authors
- Shuqun Zhang (ORCID: https://orcid.org/0000-0002-6998-7849)
- Tong Zhang (ORCID: https://orcid.org/0000-0001-7108-0974)
- Shuangyu Liu (ORCID: https://orcid.org/0000-0002-4823-6843)
- Jinhua Wang (ORCID: https://orcid.org/0000-0001-8367-0787)
- Yue Li (ORCID: https://orcid.org/0000-0002-1129-4572)
- Qian He (ORCID: https://orcid.org/0000-0003-3744-8805)
- Xiaoyan Zhou (ORCID: https://orcid.org/0000-0001-5999-7237)
- Ting Ding
- Zeqi Guo
Institutions
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Bioengineering
- Published
- 2025-04-15
- DOI
- https://doi.org/10.3390/bioengineering12040420
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00