Dearomative Ring-Opening of <i>N</i>-Fused Heteroarenes: Access to Tetrasubstituted Alkenes and Ketimines

We report a novel and efficient strategy for constructing tetrasubstituted alkenes and α-iminonitriles from 3-aminoindolizines and 3-aminoimidazo[1,2-<i>a</i>]pyridines. This approach involves a dearomative ring-opening of <i>N</i>-fused heteroaromatic amines coupled to a DDQ-mediated oxidative process under mild, metal-free conditions. The methodology demonstrates broad substrate scope, excellent functional group tolerance, and scalability, offering a versatile platform for synthesizing complex alkenes and nitrile-containing frameworks.