Developing a New Stool Test for Colorectal Cancer Screening, the multitargetFIT (mtFIT)
Early detection of colorectal cancer (CRC) through screening is the most effective method to reduce morbidity as well as mortality from this disease. Fecal immunochemical test (FIT)-based screening has shown to be effective, especially in multi-round population-based screening. However, its sensitivity and specificity are suboptimal, leaving room for improvement. In this perspective, the development journey of a new screening test, the multitargetFIT (mtFIT), which outperforms FIT, is described from discovery down to large-scale clinical utility testing and health technology assessment.
Authors
- Meike de Wit (ORCID: https://orcid.org/0000-0003-1850-0831)
- Manon C.W. Spaander (ORCID: https://orcid.org/0000-0002-9103-9757)
- Evelien Dekker (ORCID: https://orcid.org/0000-0002-4363-0745)
- Veerle M.H. Coupé (ORCID: https://orcid.org/0000-0002-9553-9791)
- Monique Esther van Leerdam (ORCID: https://orcid.org/0000-0002-5719-3208)
- Gerrit A. Meijer (ORCID: https://orcid.org/0000-0003-0330-3130)
- Beatriz G. Carvalho (ORCID: https://orcid.org/0000-0003-4903-399X)
Institutions
- Erasmus MC (NL)
- The Netherlands Cancer Institute (NL)
- University Medical Center Utrecht (NL)
- Oncode Institute (NL)
- Erasmus MC Cancer Institute (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Digestive Diseases and Sciences
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1007/s10620-025-08919-x
- Citations
- 2
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 2.09