Histopathological Study of Endometrial Biopsies in Perimenopausal and Post Menopausal Women - A Study at Tertiary Care Hospital

Introduction: Evaluation of Endometrial biopsies and curettings provides important information regarding structural and functional pathology and identifying causes of bleeding. Other indications include evacuation of conceptus, abortions or retained tissues and also evaluating benign, premalignant and malignant pathological causes. Objectives: To determine clinical features in patients of perimenopausal and postmenopausal age group and to describe their spectrum of histopathological findings. Material and Methods: This study was conducted on endometrial biopsies of total 252 patients; at the pathology department, C U Shah Medical College, Surendranagar, Gujarat; for 3 years period from January 2022 to December 2024. Cases were grouped according to their menstrual status-perimenopausal and post-menopausal period as well as according to their presenting complaints. Results: 252 cases included 72 post-menopausal and 180 perimenopausal women, from which 221 cases presented with bleeding -158 cases of perimenopausal and 63 cases of post-menopausal bleeding. Other 31 patients without bleeding presented with abdominal pain or whitish discharge. Histopathological findings includes 14.7% benign conditions, 29% pre malignant conditions and 5.2% of malignancy. Rest 48% showed other miscellaneous findings. Conclusion: Most common complaint in these age groups is AUB caused by Endometrial Hyperplasia without atypia and others conditions like hormonal imbalance and disordered endometrium.