Colon cancer exosome-associated HSP90B1 initiates pre-metastatic niche formation in the liver by polarizing M1 macrophage into M2 phenotype
CRC-derived exosomes promote liver metastasis by forming an immunosuppressive PMN through HSP90B1. Targeting HSP90B1 in CRC exosomes may offer a new therapeutic strategy to prevent liver metastasis and improve patient outcomes.
Authors
- Ning Deng (ORCID: https://orcid.org/0000-0002-3199-8243)
- Jingyi Zhao (ORCID: https://orcid.org/0000-0003-3795-4257)
- ShuJie Li
- QiuMeng Liu
- Xiaoping Chen (ORCID: https://orcid.org/0000-0003-4440-881X)
- Xue Fu
- Qi Cheng (ORCID: https://orcid.org/0000-0002-3460-3075)
- Li Jiang (ORCID: https://orcid.org/0000-0002-2286-9132)
Institutions
- Union Hospital (HK)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Health and Family Planning Commission (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Hubei University (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1186/s13062-025-00623-0
- Citations
- 7
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province