KLF6-mediated glutamine metabolism governs odontogenic differentiation and matrix mineralization of dental pulp stem cells
Our study shows that KLF6 mediates biomineralization in the newly generated functional odontoblast-like cells differentiated from hDPSCs by altering cell metabolism preferences. KLF6 facilitated glutamine influx into the TCA cycle, leading to increased deposition of citrate in the ECM.These findings may inspire the development of novel strategies for reparative dentin formation.
Authors
- Zhenyuan Xu (ORCID: https://orcid.org/0000-0001-5219-3842)
- Xiatong Zhang
- Wenzhi Wu (ORCID: https://orcid.org/0009-0001-6912-1623)
- Zhuo Chen (ORCID: https://orcid.org/0000-0001-8247-7387)
- Xiaoyuan Huang
- Zhijian Xie (ORCID: https://orcid.org/0000-0002-1982-3176)
- Yulian Zhang (ORCID: https://orcid.org/0009-0009-6085-858X)
Institutions
- Zhejiang Cancer Hospital (CN)
- Stomatology Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1186/s13287-025-04308-3
- Citations
- 2
- Primary Topic
- Genetic Syndromes and Imprinting
- Type
- article
- Field-Weighted Citation Impact
- 3.63
Funders
- National Natural Science Foundation of China