Use of Metagenomic Microbial Plasma Cell-Free DNA Next-Generation Sequencing Assay in Outpatient Rheumatology Practice
In this large retrospective cohort study, the most frequent reason for KT utilization was an atypical presentation of rheumatic disease. One out of 4 positive KTs altered the final diagnosis and treatment. False negative rates were low. KT has utility in outpatient rheumatology assessments. Further delineation of which patients are best suited for KT testing remains to be defined.
Authors
- Rachel Jenkins (ORCID: https://orcid.org/0000-0003-3549-6117)
- Matthew J. Koster (ORCID: https://orcid.org/0000-0002-2895-6755)
- Matthew J. Samec (ORCID: https://orcid.org/0000-0002-4736-6582)
- Kenneth J. Warrington (ORCID: https://orcid.org/0000-0001-7708-2487)
- Courtney A. Arment (ORCID: https://orcid.org/0000-0002-6975-6530)
- John M. Davis (ORCID: https://orcid.org/0000-0002-9710-8143)
Institutions
- Mayo Clinic (US)
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- The Journal of Rheumatology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.3899/jrheum.2024-1211
- Primary Topic
- Hematological disorders and diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00