Synaptic inhibitory dynamics drive benzodiazepine response in pediatric status epilepticus
Together, our findings confirm that alterations in synaptic inhibition underlie BZP response during pediatric SE. More broadly, this work further demonstrates the utility of computational modeling to validate insights from basic science in clinically accessible recordings in neurological disorders characterized by abnormal brain states.
Authors
- Giorgio Selmin (ORCID: https://orcid.org/0000-0002-4252-6495)
- Tommaso Fedele
- Anne Steinberg (ORCID: https://orcid.org/0000-0002-5037-1606)
- Georgia Ramantani (ORCID: https://orcid.org/0000-0002-7931-2327)
- Richard Rosch (ORCID: https://orcid.org/0000-0002-0316-5818)
- Richard J. Burman (ORCID: https://orcid.org/0000-0003-3107-7871)
Institutions
- National Research University Higher School of Economics (RU)
- King's College London (GB)
- University of Zurich (CH)
- Oxford Research Group (GB)
- University of Oxford (GB)
- University Children's Hospital Zurich (CH)
- University College London (GB)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1111/epi.18398
- Citations
- 2
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- National Science Foundation
- Wellcome Trust
- European Commission
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung