Pharmacokinetics of continuous infusion ceftolozane/tazobactam in two patients with extensive total body surface area burns
These cases highlight the variability of drug exposure in patients with extensive TBSA burn injuries and support continuous infusion β-lactam therapy as a proactive strategy to optimize pharmacodynamic target attainment when pharmacokinetics are unpredictable.
Authors
- Juan J. Calix (ORCID: https://orcid.org/0000-0003-0424-6721)
- Tyson Kilpatrick
- Emma Graffice (ORCID: https://orcid.org/0000-0001-5210-9778)
- Josep Olivet
- Matthew L Brown (ORCID: https://orcid.org/0000-0001-5346-0690)
- Megan H. Amerson-Brown (ORCID: https://orcid.org/0000-0002-1545-7826)
- Hanna F. Roenfanz (ORCID: https://orcid.org/0000-0002-0990-0932)
- Joseph L. Kuti (ORCID: https://orcid.org/0000-0002-4464-3126)
- David P. Nicolau (ORCID: https://orcid.org/0000-0002-4148-0165)
Institutions
- Hartford Hospital (US)
- University of Alabama at Birmingham Hospital (US)
- University of Alabama at Birmingham (US)
- Hartford Financial Services (United States)
Publication Details
- Journal
- Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1002/phar.70019
- Citations
- 4
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 5.58