During high salt treatment myeloid p38α/MAPK fosters osteoclast activity and inflammatory macrophage responses promoting orthodontic tooth movement
We conclude that myeloid p38α/MAPK promotes macrophage <i>Ptgs2</i> expression and osteoclast activity in response to extracellular salt levels, thereby supporting orthodontic tooth movement.
Authors
- Christian Kirschneck (ORCID: https://orcid.org/0000-0001-9473-8724)
- Eva Paddenberg (ORCID: https://orcid.org/0000-0001-8207-5257)
- Agnes Schröder (ORCID: https://orcid.org/0000-0001-6010-9831)
- Jonathan Jantsch (ORCID: https://orcid.org/0000-0001-6944-2913)
- Florian Fischer
- Peter Proff
- Beatrice Reinert
Institutions
- University of Cologne (DE)
- University Hospital Bonn (DE)
- University Hospital Regensburg (DE)
- Institute of Medical Microbiology and Hygiene (DE)
- University Hospital Cologne (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1571268
- Citations
- 2
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Deutsche Forschungsgemeinschaft