Targeting FASN enhances cisplatin sensitivity via SLC7A11-mediated ferroptosis in cervical cancer
Targeting FASN enhances cisplatin sensitivity in CC by promoting SLC7A11-mediated ferroptosis. TVB-2640 combined with cisplatin had superior synergistic antitumor effects in cisplatin-resistant CC models.
Authors
- Shuzhong Yao (ORCID: https://orcid.org/0000-0002-5145-5705)
- Mengxun Wei
- Qiqiao Du (ORCID: https://orcid.org/0000-0003-4053-1044)
- Qiaojian Zou
- Qianrun Chen
- Junxiu Liu (ORCID: https://orcid.org/0000-0002-7892-6343)
- Zhihang Peng
- Xiaojun Wang (ORCID: https://orcid.org/0000-0002-6802-2623)
- Yili Chen (ORCID: https://orcid.org/0000-0002-1409-631X)
- Liu Du
- Xiaoying Lin (ORCID: https://orcid.org/0009-0008-0194-8895)
- Qiuwen Mai (ORCID: https://orcid.org/0000-0002-9039-9435)
- Shuyi Wang
- C.-W. Chi
- Karima Abdugheni
Institutions
- Qingdao University (CN)
- Sun Yat-sen University (CN)
- Qingdao Municipal Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1016/j.tranon.2025.102396
- Citations
- 10
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 15.18