Population-Specific Differences in Pathogenic Variants of Genes Associated with Monogenic Parkinson’s Disease
Our findings reveal substantial population-specific differences in the allele frequencies of pathogenic variants linked to monogenic PD, emphasising the need for broader genetic studies beyond European populations. These insights have important implications for PD research, genetic screening, and understanding the pathogenesis of PD in diverse populations.
Authors
- Luis M. García‐Marín (ORCID: https://orcid.org/0000-0003-4731-6558)
- Wei Yin Lim (ORCID: https://orcid.org/0000-0002-2612-0604)
- Miguel E. Rentería (ORCID: https://orcid.org/0000-0003-4626-7248)
- Natalia Ogonowski (ORCID: https://orcid.org/0000-0002-0090-3184)
- Victor Flores‐Ocampo (ORCID: https://orcid.org/0009-0006-5562-1260)
- Jue‐Sheng Ong (ORCID: https://orcid.org/0000-0002-6062-710X)
- Kishore Raj Kumar (ORCID: https://orcid.org/0000-0003-3482-6962)
- Claudia Gonzaga‐Jauregui (ORCID: https://orcid.org/0000-0002-4667-3679)
- Dennis Yeow (ORCID: https://orcid.org/0000-0001-7534-7007)
Institutions
- The University of Sydney (AU)
- Garvan Institute of Medical Research (AU)
- Queensland University of Technology (AU)
- The University of Queensland (AU)
- QIMR Berghofer Medical Research Institute (AU)
- Concord Repatriation General Hospital (AU)
- UNSW Sydney (AU)
- St Vincent's Health (AU)
- Neuroscience Research Australia (AU)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Genes
- Published
- 2025-04-15
- DOI
- https://doi.org/10.3390/genes16040454
- Citations
- 4
- Primary Topic
- Neurological diseases and metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.37
Funders
- Medical Research Council
- National Health and Medical Research Council