Sustained NPSLE-like phenotype in the absence of systemic lupus-like disease in TLR7-deficient B6.Nba2 mice
While systemic lupus-like disease in the B6.Nba2 mouse model is dependent on TLR7, NPSLE development is not and may be influenced by TLR4 and TLR9 signaling. Thus, there may be separate mechanisms driving peripheral SLE compared to NPSLE with possible implications for pharmacologic management.
Authors
- James Sullivan (ORCID: https://orcid.org/0000-0001-5853-1590)
- Audrey Kwun
- Gabrielle M. Mey (ORCID: https://orcid.org/0000-0002-3952-849X)
- S Liu
- Tara M. DeSilva (ORCID: https://orcid.org/0000-0002-1212-5762)
- John Shelestak (ORCID: https://orcid.org/0000-0001-8766-3461)
- Trine N. Jørgensen (ORCID: https://orcid.org/0000-0001-8566-4647)
- Katharine Merritt
Institutions
- Cleveland Clinic (US)
- Cleveland Foundation (US)
- Cleveland Clinic Lerner College of Medicine (US)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1016/j.bbi.2025.04.017
- Citations
- 3
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- U.S. Department of Defense
- National Institute of Allergy and Infectious Diseases