Hyperammonaemia during allogeneic stem cell transplantation: distinct aetiology, importance of recognition and proposed treatment algorithm

Hyperammonaemia during stem cell transplant is a distinct biochemical and clinical entity. It has a different pathological driver from other common forms of hyperammonaemia. Early recognition of this pathology and an understanding of its biochemical, pathological and microbiological aspects inform an aggressive management algorithm.

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Publication Details

Journal
Internal Medicine Journal
Published
2025-04-15
DOI
https://doi.org/10.1111/imj.70052
Primary Topic
Metabolism and Genetic Disorders
Type
article
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article

Hyperammonaemia during allogeneic stem cell transplantation: distinct aetiology, importance of recognition and proposed treatment algorithm

Timothy Nicholas Fazio, David Ritchie, Jeremy Cajina-Clark, James Anstey
Internal Medicine Journal
Metabolism and Genetic Disorders
article

Hyperammonaemia during allogeneic stem cell transplantation: distinct aetiology, importance of recognition and proposed treatment algorithm

Timothy Nicholas Fazio, David Ritchie, Jeremy Cajina-Clark, James Anstey
article en

Abstract

Hyperammonaemia during stem cell transplant is a distinct biochemical and clinical entity. It has a different pathological driver from other common forms of hyperammonaemia. Early recognition of this pathology and an understanding of its biochemical, pathological and microbiological aspects inform an aggressive management algorithm.

Internal Medicine JournalVol. 55(5)
The Royal Melbourne Hospital (AU), Peter MacCallum Cancer Centre (AU)
Good health and well-being
Openalex Percentile: Top 90%
Metabolism and Genetic Disorders
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