Cystic Fibrosis-related neurodegenerative disease associated with tauopathy and cognitive decline in aged CF mice
Aging CF mice develop tauopathy, cognitive decline, LTP impairment, microglial activation, and neurodegeneration that is not experienced by age-matched WT littermates, a condition herein termed cystic fibrosis-related neurodegeneration (CFND). These findings suggest that pwCF may be at risk for tauopathy-related neurodegeneration and cognitive impairment with aging.
Authors
- Jung A. Woo (ORCID: https://orcid.org/0000-0002-9194-1361)
- Rebecca Darrah (ORCID: https://orcid.org/0000-0003-2288-9704)
- Warren Ward
- Thomas J. Kelley (ORCID: https://orcid.org/0000-0001-9236-7907)
- Deborah A. Corey
- Andrew A. Pieper (ORCID: https://orcid.org/0000-0001-6299-6577)
- David E. Kang (ORCID: https://orcid.org/0000-0002-7132-821X)
- Sarah Barker (ORCID: https://orcid.org/0000-0002-3927-6966)
- Edwin Vázquez‐Rosa (ORCID: https://orcid.org/0009-0005-4508-5217)
- Xinming Wang
- Danica F. Patton-Parfyonov
- Nichele Abeyesundere
Institutions
- University Hospitals of Cleveland (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Journal of Cystic Fibrosis
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1016/j.jcf.2025.04.003
- Citations
- 2
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- U.S. Department of Defense
- U.S. Department of Veterans Affairs
- Case Western Reserve University
- National Institutes of Health
- National Institute on Aging
- National Institute of General Medical Sciences