Genetic landscape of uveal melanoma in Southeast Asia: high 1q gains and unique patterns of metastasis risk

This study highlights significant genetic differences between SEA and Western UM patients, particularly the lower incidence of monosomy 3 in SEA patients. This preliminary observation raises concerns about the reliability of using BAP1 loss alone, assessed through gene expression or immunostaining, as a sole marker for metastasis surveillance and risk stratification in Asian UM patients. These findings underscore the need for further research to determine whether additional genetic markers are required to improve prognostic accuracy in this population. Expanding molecular profiling in SEA would improve risk stratification and inform treatment strategies, while collaborative research with larger cohorts is essential to validate these findings and refine prognostic models globally.

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Publication Details

Journal
Eye and Vision
Published
2025-04-16
DOI
https://doi.org/10.1186/s40662-025-00430-8
Citations
2
Primary Topic
Ocular Oncology and Treatments
Type
article
Field-Weighted Citation Impact
3.41

Funders

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article

Genetic landscape of uveal melanoma in Southeast Asia: high 1q gains and unique patterns of metastasis risk

Evelyn Yee Hsieh Heng, Jason Yongsheng Chan, Sim Leng Tien, Anita Sook Yee Chan et al.
2 citations
Eye and Vision
Ocular Oncology and Treatments
3.41
article

Genetic landscape of uveal melanoma in Southeast Asia: high 1q gains and unique patterns of metastasis risk

Evelyn Yee Hsieh Heng, Jason Yongsheng Chan, Sim Leng Tien, Anita Sook Yee Chan, Chuanfei Chen, Mona Meng Wang, Gavin Siew Wei Tan, Alvin Soon Tiong Lim, Sunny Shen
article en
2 citations

Abstract

This study highlights significant genetic differences between SEA and Western UM patients, particularly the lower incidence of monosomy 3 in SEA patients. This preliminary observation raises concerns about the reliability of using BAP1 loss alone, assessed through gene expression or immunostaining, as a sole marker for metastasis surveillance and risk stratification in Asian UM patients. These findings underscore the need for further research to determine whether additional genetic markers are required to improve prognostic accuracy in this population. Expanding molecular profiling in SEA would improve risk stratification and inform treatment strategies, while collaborative research with larger cohorts is essential to validate these findings and refine prognostic models globally.

Eye and VisionVol. 12(1)
University of Turku (FI), SingHealth (SG), Singapore General Hospital (SG), Singapore National Eye Center (SG), SingHealth Duke-NUS Academic Medical Centre (SG), Singapore Eye Research Institute (SG), Duke-NUS Medical School (SG), National Cancer Centre Singapore (SG)
Medical Research Council, National Medical Research Council
Life below water
Openalex Percentile: Top 9%
Ocular Oncology and Treatments
3.41
DOIOpen Access PDFOpenAlex
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Genetic landscape of uveal melanoma in Southeast Asia: high 1q gains and unique patterns of metastasis risk — Evelyn Yee Hsieh Heng, Jason Yongsheng Chan, et al. · Eye and Vision (2025) | TGRS Research Map | TGRS