Formulation and evaluation of Niosomal cream from moringa leaf extract for enhanced Antifungal Activity

Niosomal drug delivery systems have gained attention for enhancing the bioavailability and efficacy of pharmaceutical formulations. This study explores the formulation and evaluation of a niosomal antifungal cream incorporating Moringa oleifera leaf extract. Moringa leaves contain bioactive compounds with antifungal properties, making them a potential alternative to synthetic antifungal agents. Niosomes, as vesicular carriers, improve drug stability, penetration, and controlled release, enhancing therapeutic effects. The formulated cream was characterized for particle size, entrapment efficiency, pH, spreadability, and in vitro antifungal activity against common fungal strains. The results demonstrated that the niosomal formulation improved drug retention and prolonged antifungal activity compared to conventional creams. The study suggests that a niosomal antifungal cream containing Moringa leaf extract could be an effective natural treatment for fungal infections, offering a promising alternative to conventional antifungal therapies. Keywords: Moringa oleifera, niosomal cream, antifungal activity, drug delivery, dermatophytosis, Candida albicans, vesicular drug