Protective Effects of Ejiao on Chronic Obstructive Pulmonary Disease in Mice via Modulation of the ER/AKT/NF-κB Pathway
Chronic obstructive pulmonary disease (COPD) is an irreversible inflammatory lung disease. Studies have shown that macrophages and estrogen receptors play a pivotal regulatory role in the development of COPD. Ejiao (Colla Corii Asini, CCA, or donkey-hide gelatin), a traditional Chinese medicine, has anti-inflammatory and lung function-protective effects, but its specific mechanism in COPD remains unclear. This study aimed to explore the immunomodulatory effects of Ejiao on COPD, focusing on its impact on inflammatory pathways and macrophages.
Authors
- Hongtao Jin (ORCID: https://orcid.org/0000-0002-0638-707X)
- Xiaoyun Ye
- Pingping Shang
- Siman Sun
- Wanfang Li (ORCID: https://orcid.org/0000-0002-2544-1756)
- Z. Xu (ORCID: https://orcid.org/0009-0002-4758-654X)
- Haiyan Jiang (ORCID: https://orcid.org/0000-0003-2756-4335)
- Bin Wang (ORCID: https://orcid.org/0000-0002-8305-8667)
- Jie Li (ORCID: https://orcid.org/0000-0002-6175-3167)
- Chuan Wang (ORCID: https://orcid.org/0000-0003-3817-7402)
- Tianyu Zhou (ORCID: https://orcid.org/0000-0002-8785-8493)
- Fuwei Xie (ORCID: https://orcid.org/0009-0008-2395-7151)
- Xiaoyu Fan (ORCID: https://orcid.org/0009-0005-2754-2269)
Publication Details
- Journal
- Future Integrative Medicine
- Published
- 2025-04-16
- DOI
- https://doi.org/10.14218/fim.2025.00003
- Citations
- 1
- Primary Topic
- Traditional Chinese Medicine Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.38
Funders
- National Natural Science Foundation of China