Optogenetic induction of TDP-43 aggregation impairs neuronal integrity and behavior in Caenorhabditis elegans
We present an optogenetic C. elegans model of TDP-43 proteinopathy that provides insight into the neuropathological mechanisms of TDP-43 aggregates. Our model serves as a promising tool for identifying therapeutic targets for TDP-43 proteinopathy.
Authors
- Kyung Hwan Park
- Chanbin Park
- Jongho Lee (ORCID: https://orcid.org/0000-0003-0398-4220)
- Kyung Won Kim (ORCID: https://orcid.org/0000-0002-8252-6203)
- Seung Chan Kim (ORCID: https://orcid.org/0000-0002-1117-399X)
- Evelyn Yu
- Sooji Choi
Institutions
- Hallym University (KR)
- Chungnam National University (KR)
- Hallym Polytechnic University (KR)
- Korea Research Institute of Standards and Science (KR)
Publication Details
- Journal
- Translational Neurodegeneration
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1186/s40035-025-00480-x
- Citations
- 4
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 5.56
Funders
- National Research Foundation
- Ministry of Food and Drug Safety
- National Research Foundation of Korea
- Ministry of Education, Science and Technology
- Ministry of Science and ICT, South Korea
- National Institutes of Health