Synthesis of Spirocyclic Phthalans via Ru-Catalyzed [2 + 2 + 2] Cycloaddition of 1,6-Diynes with Ex-Situ Generated Acetylene
Spirocyclic motifs are attracting increasing attention owing to their three-dimensional geometries that endow bioactive molecules with superior physical and biological properties. We developed an efficient method for constructing spirocyclic phthalans via the Ru-catalyzed [2 + 2 + 2] cycloaddition of cycloalkanone-derived 1,6-diynes with acetylene gas ex-situ<i>-</i>generated from calcium carbide and H<sub>2</sub>O.
Authors
- Kenichi Yoshimura (ORCID: https://orcid.org/0000-0001-7393-6932)
- Yoshihiko Yamamoto (ORCID: https://orcid.org/0000-0001-8544-6324)
- Takeshi Yasui (ORCID: https://orcid.org/0000-0002-7630-8736)
Institutions
- Nagoya University (JP)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1021/acs.joc.5c00486
- Citations
- 3
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 2.81