METTL3 promotes an immunosuppressive microenvironment in bladder cancer via m6A-dependent CXCL5/CCL5 regulation
These findings highlight METTL3 as a key regulator of the immune microenvironment in BLCA and a promising therapeutic target to improve immunotherapy outcomes. Targeting METTL3 could potentially enhance the efficacy of ICIs in patients with BLCA.
Authors
- Ejun Peng (ORCID: https://orcid.org/0000-0003-1736-0494)
- Kun Tang (ORCID: https://orcid.org/0000-0002-8418-143X)
- Jian Wu (ORCID: https://orcid.org/0000-0001-7065-9917)
- Qiu Huang (ORCID: https://orcid.org/0000-0002-2966-6450)
- Yu He (ORCID: https://orcid.org/0000-0002-8155-4536)
- Yonghua Tong
- Zhihua Wang (ORCID: https://orcid.org/0000-0003-1842-0065)
- Zhiqiang Chen (ORCID: https://orcid.org/0000-0001-7160-8345)
- Haojie Shang
- Xia Ding (ORCID: https://orcid.org/0000-0003-0388-5388)
- Xiaoyu Liang (ORCID: https://orcid.org/0000-0002-3038-9374)
Institutions
- Sun Yat-sen University (CN)
- Key Laboratory of Guangdong Province (CN)
- Sun Yat-sen University Cancer Center (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1136/jitc-2024-011108
- Citations
- 11
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 8.87
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province