CD155 blockade enhances allogeneic natural killer cell-mediated antitumor response against osteosarcoma
These results demonstrate the safety and efficacy of infusing alloNK cells with CD155 blockade to mount a GVT effect against OS and show benefits are in part through DNAM-1. Defining the hierarchy of receptors that govern alloNK responses is critical to translating alloNK cell infusions and immune checkpoint inhibition for solid tumors treated with alloBMT.
Authors
- John A. Kink (ORCID: https://orcid.org/0000-0002-4003-6468)
- Madison F Phillips
- Fernanda Szewc (ORCID: https://orcid.org/0000-0003-1608-9321)
- Monica Moonkyung Cho (ORCID: https://orcid.org/0000-0002-6708-9578)
- Longzhen Song
- Christian M. Capitini (ORCID: https://orcid.org/0000-0002-2276-6731)
- Aicha Quamine (ORCID: https://orcid.org/0000-0002-9049-7078)
- Paul D. Bates
- Matthew H. Forsberg (ORCID: https://orcid.org/0000-0002-0514-6354)
- Amy K. Erbe
- David P Turicek (ORCID: https://orcid.org/0000-0003-0837-2688)
- Emily O Lafeber
- Devin M Burpee
- Lei Shi (ORCID: https://orcid.org/0000-0002-6510-7904)
- Johnathan Ebben (ORCID: https://orcid.org/0000-0002-4120-8751)
- Jillian M Kline
- S Amanda
Institutions
- University of Wisconsin–Madison (US)
- University of Wisconsin Carbone Cancer Center (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1136/jitc-2023-008755
- Citations
- 6
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 4.78
Funders
- National Science Foundation
- National Institutes of Health
- National Cancer Institute
- National Institute of General Medical Sciences