The impact of dosage timing for inhaled corticosteroids in asthma: a randomised three-way crossover trial
OD<sub>PM</sub> better suppresses the nocturnal dip in lung function and peak of blood eosinophil counts compared with BD and OD<sub>AM</sub>; this was without an increase in adverse events. Future trials are warranted to validate these findings in real-life settings and to determine which population may best benefit from chronotherapy.
Authors
- Angela Simpson (ORCID: https://orcid.org/0000-0003-2733-6666)
- Ran Wang (ORCID: https://orcid.org/0000-0003-3324-969X)
- Andrew Loudon (ORCID: https://orcid.org/0000-0003-3648-445X)
- David Ray (ORCID: https://orcid.org/0000-0002-4739-6773)
- Hannah Durrington (ORCID: https://orcid.org/0000-0002-9990-9446)
- Dave Singh (ORCID: https://orcid.org/0000-0001-8918-7075)
- Robert Maidstone (ORCID: https://orcid.org/0000-0002-3482-3246)
Institutions
- University of Manchester (GB)
- Oxford Centre for Diabetes, Endocrinology and Metabolism (GB)
- Oxford BioMedica (United Kingdom) (GB)
- Wythenshawe Hospital (GB)
- NIHR Manchester Biomedical Research Centre (GB)
Publication Details
- Journal
- Thorax
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1136/thorax-2024-222073
- Citations
- 8
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 9.31
Funders
- Asthma and Lung UK
- Medical Research Council