GL‐V9 inhibits Caspase‐11 activation‐induced pyroptosis by suppressing ALOX12‐mediated lipid peroxidation to alleviate sepsis
GL-V9 exerts a powerful anti-sepsis effect in vivo, which is associated with the inhibition of Caspase-11 activation. Mechanistically, GL-V9 may block LPS release from early endosomes by inhibiting ALOX12-mediated lipid peroxidation. This suggests that GL-V9 is a potential candidate for the treatment of sepsis.
Authors
- Na Lu (ORCID: https://orcid.org/0000-0002-4981-5281)
- Chunyang Gu (ORCID: https://orcid.org/0000-0003-1283-1701)
- Jiaying Du
- Dongsheng Bai (ORCID: https://orcid.org/0000-0003-3752-0694)
- Li Chen (ORCID: https://orcid.org/0000-0002-4655-9024)
- Yuxiang Wang (ORCID: https://orcid.org/0000-0002-1049-8469)
- Yue Zhao (ORCID: https://orcid.org/0000-0002-5767-1740)
- Jiawei Zhao
- Lulu Zhang (ORCID: https://orcid.org/0000-0001-9337-9395)
- Chen Zhou (ORCID: https://orcid.org/0009-0006-8055-8339)
Institutions
- China Pharmaceutical University (CN)
- State Key Laboratory of Natural Medicine
- Nanjing Medical University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1111/bph.70053
- Citations
- 2
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China