Title Pending 33890

<strong>This is an accepted article with a DOI pre-assigned that is not yet published.</strong> Copper oxide nanoparticles (CuO NPs) are attracting attention due to their unique properties and diverse applications in technology and medicine. However, these nanoparticles also pose potential health risks as they can enter the human body through various exposure routes, such as inhalation. During a visit to a toxicology lab, high school students explored the adverse effects of CuO NPs under the guidance of the lab scientist and principal investigator. They learned how these particles interact with human cells, producing reactive oxygen species (ROS) and releasing copper ions. This interaction can lead to cellular stress or damage, depending on the exposure dose. Such effects have been linked to respiratory problems and damage to multiple organs in exposed workers and experimental models. The discussion highlighted the importance of balancing the benefits and risks of nanoparticle use, stressing the need for safer handling protocols and effective protective measures.&nbsp; To enhance engagement and accessibility, this information was presented in a comic format. Comics offer a creative science communication tool by combining visuals and storytelling, making complex concepts easier to understand—particularly for younger audiences such as high school students. The format encourages curiosity, supports learning through visualization, and bridges the gap between science and the general public. Through hands-on demonstrations and collaborative learning, students were inspired to contribute to ongoing research on the safe application of nanoparticles, tackling the challenges of "tiny particles” that pose “big questions" for a healthier and more sustainable future.