Baicalein prevents pregnancy loss by maintaining regulatory T cell activation through inhibition of the TLR4/NF-κB signaling pathway

Baicalein improved pregnancy outcomes by enhancing Treg function and promoting decidualization via TLR4/NF-κB pathway inhibition. These findings highlight baicalein's potential as a therapeutic agent for URSA.

Authors

Caiqun Huang (ORCID: https://orcid.org/0000-0002-5315-8931)
Jinping Ni (ORCID: https://orcid.org/0000-0002-2572-3171)
Ying Lyu (ORCID: https://orcid.org/0000-0001-7532-928X)
En-Hui Cheng

Institutions

Jiangnan University (CN)
Jinhua Academy of Agricultural Sciences (CN)
Guang Fu Hospital (CN)
Jinhua Central Hospital (CN)

Publication Details

Journal: Placenta
Published: 2025-04-15
DOI: https://doi.org/10.1016/j.placenta.2025.04.012
Citations: 4
Primary Topic: Natural product bioactivities and synthesis
Type: article
Field-Weighted Citation Impact: 3.22

Funders

Jinhua Science and Technology Bureau
Zhejiang Traditional Chinese Medicine Administration

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article

Baicalein prevents pregnancy loss by maintaining regulatory T cell activation through inhibition of the TLR4/NF-κB signaling pathway

Caiqun Huang, Jinping Ni, Ying Lyu, En-Hui Cheng

Apr 15, 2025

4 citations

Placenta

Natural product bioactivities and synthesis

3.22

article

Baicalein prevents pregnancy loss by maintaining regulatory T cell activation through inhibition of the TLR4/NF-κB signaling pathway

Caiqun Huang, Jinping Ni, Ying Lyu, En-Hui Cheng

April 15, 2025article en

4 citations

Abstract

Baicalein improved pregnancy outcomes by enhancing Treg function and promoting decidualization via TLR4/NF-κB pathway inhibition. These findings highlight baicalein's potential as a therapeutic agent for URSA.

PlacentaVol. 165

Jiangnan University (CN), Jinhua Academy of Agricultural Sciences (CN), Guang Fu Hospital (CN), Jinhua Central Hospital (CN)

Jinhua Science and Technology Bureau, Zhejiang Traditional Chinese Medicine Administration

Good health and well-being

Openalex Percentile: Top 9%

Natural product bioactivities and synthesis

3.22

DOI Open Access PDF OpenAlex

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