ROS-DRP1-mediated excessive mitochondrial fission and autophagic flux inhibition contribute to heat stress-induced apoptosis in goat Sertoli cells
In summary, these findings indicated that the mechanism of HS-induced mitochondria-dependent apoptosis in SCs is mediated by hyperactivation of the ROS-DRP1-mitochondrial fission axis and inhibition of mitochondrial autophagy. Melatonin inhibited HS-induced mitochondria-dependent apoptosis in SCs by restoring mitochondrial homeostasis. This study enhances the understanding of the mechanisms through which heat stress triggers apoptosis and provides a vision for the development of drugs against HS by targeting mitochondria in goats.
Authors
- Songmao Guo
- Fei Wen (ORCID: https://orcid.org/0009-0009-5662-7893)
- Xianzou Feng
- Jianhong Hu (ORCID: https://orcid.org/0000-0002-5833-3444)
- Shuaiqi Han
- Xing Zhang (ORCID: https://orcid.org/0000-0002-3067-4503)
- Jing Gao (ORCID: https://orcid.org/0000-0001-5099-6991)
- Guoyu Zhang (ORCID: https://orcid.org/0000-0002-4245-0742)
- Xiaoxu Chen (ORCID: https://orcid.org/0000-0003-0872-1139)
Institutions
- Agriculture and Forestry University (NP)
- North West Agriculture and Forestry University (CN)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1186/s40104-025-01180-2
- Citations
- 10
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 16.98
Funders
- Basic Research Program of Jiangsu Province