The voltage-gated sodium channel β3 subunit modulates C6 glioma cell motility independently of channel activity
Our data reveals a novel and unexpected role for the VGSC β3 subunit in orchestrating actin organization and negatively regulating cell migration in glioma cells which may potentially explain clinical correlations with glioma severity.
Authors
- Hengrui Liu (ORCID: https://orcid.org/0000-0002-5369-3926)
- Laura M. Machesky (ORCID: https://orcid.org/0000-0002-7592-9856)
- Christopher Huang (ORCID: https://orcid.org/0000-0001-9553-6112)
- Fernando Hernández (ORCID: https://orcid.org/0000-0001-5158-2029)
- Samir W. Hamaia
- Antony P. Jackson (ORCID: https://orcid.org/0000-0002-2895-7387)
- Jieling Weng (ORCID: https://orcid.org/0000-0001-9634-4083)
- Samantha C. Salvage (ORCID: https://orcid.org/0000-0002-5793-2349)
- Lisa Dobson (ORCID: https://orcid.org/0000-0002-9354-0123)
- Christopher A. Beaudoin (ORCID: https://orcid.org/0000-0002-0232-0281)
Institutions
- University of Cambridge (GB)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Bridge University (SS)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1016/j.bbadis.2025.167844
- Citations
- 35
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 31.82
Funders
- Cancer Research UK
- British Heart Foundation
- Cancer Research UK Cambridge Institute, University of Cambridge