The mitochondrial protectant SS31 optimized decellularized Wharton's jelly scaffold improves allogeneic chondrocyte implantation-mediated articular cartilage repair
Our study was the first to successfully load the mitochondrial protectant SS31 onto a DUCWJ hydrogel scaffold for localized drug delivery. This method is highly efficacious in repairing cartilage defects and offers a promising new avenue for the treatment of such conditions.
Authors
- Ziheng Xu (ORCID: https://orcid.org/0000-0001-6303-5823)
- Zheng Guo (ORCID: https://orcid.org/0000-0002-0932-4568)
- F Li (ORCID: https://orcid.org/0009-0003-1151-8892)
- Yongkang Yang (ORCID: https://orcid.org/0000-0002-0333-7712)
- Ruiyang Zhang
- Quanyi Guo (ORCID: https://orcid.org/0000-0001-7154-2227)
- Runmeng Li
- Shuyun Liu (ORCID: https://orcid.org/0000-0003-3865-4547)
- Hao Li (ORCID: https://orcid.org/0000-0003-4704-3174)
- Yuhao Mu
- Chao Wang
- Tianze Gao
Institutions
- Nankai University (CN)
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1016/j.jot.2025.03.023
- Citations
- 3
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality
- General Hospital of People’s Liberation Army
- National Key Research and Development Program of China