Ruxolitinib suppresses tumor growth in PTEN-deficient glioblastoma by inhibiting the STAT3-PDL1 axis-mediated the M2 polarization of macrophages
The STAT3-PDL1 axis plays a crucial role in the M2 polarization of macrophages in PTEN-deficient GBM. The blockade of the STAT3-PDL1 axis by Ruxolitinib regulates the anti-tumor immune response and curtails tumor progression in PTEN-deficient GBM, highlighting its significant clinical implications.
Authors
- Penglei Yao
- Guo Xin
- Jian Ma (ORCID: https://orcid.org/0000-0002-1056-8519)
- Guangzhi Wang (ORCID: https://orcid.org/0000-0002-4677-1041)
- Huanyu Ju
- Yue Wang (ORCID: https://orcid.org/0000-0003-4536-9904)
- Mian Guo (ORCID: https://orcid.org/0000-0002-1475-1935)
- Aohua Song
Institutions
- Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1016/j.intimp.2025.114629
- Citations
- 1
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 1.05