Population Pharmacokinetic Analysis of Cefoperazone-Sulbactam in Pediatric Patients: Simultaneous Analysis of Plasma and Urine Data for Optimal Dosing Regimens

This study described population PK models of cefoperazone and sulbactam detailing the excretion process with urine data in pediatric patients and developed optimal dosing regimens of cefoperazone-sulbactam including extended infusion in consideration with pathogens, based on PK/PD simulation.

Authors

Takahisa Yano (ORCID: https://orcid.org/0000-0002-3385-6126)
Kazuro Ikawa (ORCID: https://orcid.org/0000-0002-9349-4067)
Noriyuki Ishihara (ORCID: https://orcid.org/0000-0002-1144-3929)
Hiroki Tamaki
Tetsushu Onita (ORCID: https://orcid.org/0000-0003-1174-0787)
Yui Sano

Institutions

Hiroshima University (JP)
Shimane University Hospital (JP)

Publication Details

Journal: The Pediatric Infectious Disease Journal
Published: 2025-04-11
DOI: https://doi.org/10.1097/inf.0000000000004832
Citations: 1
Primary Topic: Antibiotics Pharmacokinetics and Efficacy
Type: article
Field-Weighted Citation Impact: 1.39

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article

Population Pharmacokinetic Analysis of Cefoperazone-Sulbactam in Pediatric Patients: Simultaneous Analysis of Plasma and Urine Data for Optimal Dosing Regimens

Takahisa Yano, Kazuro Ikawa, Noriyuki Ishihara, Hiroki Tamaki et al.

Apr 11, 2025

1 citations

The Pediatric Infectious Disease Journal

Antibiotics Pharmacokinetics and Efficacy

1.39

article

Population Pharmacokinetic Analysis of Cefoperazone-Sulbactam in Pediatric Patients: Simultaneous Analysis of Plasma and Urine Data for Optimal Dosing Regimens

Takahisa Yano, Kazuro Ikawa, Noriyuki Ishihara, Hiroki Tamaki, Tetsushu Onita, Yui Sano

April 11, 2025article en

1 citations

Abstract

This study described population PK models of cefoperazone and sulbactam detailing the excretion process with urine data in pediatric patients and developed optimal dosing regimens of cefoperazone-sulbactam including extended infusion in consideration with pathogens, based on PK/PD simulation.

The Pediatric Infectious Disease JournalVol. 44(9)

Hiroshima University (JP), Shimane University Hospital (JP)

Good health and well-being

Openalex Percentile: Top 21%

Antibiotics Pharmacokinetics and Efficacy

1.39

DOI Source OpenAlex

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Population Pharmacokinetic Analysis of Cefoperazone-Sulbactam in Pediatric Patients: Simultaneous Analysis of Plasma and Urine Data for Optimal Dosing Regimens — Takahisa Yano, Kazuro Ikawa, et al. · The Pediatric Infectious Disease Journal (2025) | TGRS Research Map | TGRS