Parafacial GABAergic neurone ablation induces behavioural resistance to volatile anaesthetic-induced hypnosis without reducing sleep
There was an unexpected dissociation in which destruction of up to 70-80% of PZ<sup>GABA</sup> neurones was sufficient to alter anaesthetic susceptibility behaviourally without causing insomnia or altering sleep pressure. These findings suggest that PZ<sup>GABA</sup> neurones are more critical to drug-induced hypnosis than to the regulation of natural sleep and arousal.
Authors
- Max B. Kelz (ORCID: https://orcid.org/0000-0002-2803-6078)
- Andrzej Z. Wasilczuk (ORCID: https://orcid.org/0000-0002-1492-2319)
- Brendan T Keenan (ORCID: https://orcid.org/0000-0002-9070-847X)
- Naoki Shimizu (ORCID: https://orcid.org/0000-0002-1892-5795)
- Allan I Pack (ORCID: https://orcid.org/0000-0002-2879-0484)
- Sarah L. Reitz (ORCID: https://orcid.org/0000-0002-5863-671X)
- Toshihiro Imamura (ORCID: https://orcid.org/0000-0002-4722-3952)
- Jie Lian (ORCID: https://orcid.org/0000-0002-9752-8260)
- M Imamura
Institutions
- Children's Hospital of Philadelphia (US)
- St. Marianna University School of Medicine (JP)
- University of Pennsylvania (US)
Publication Details
- Journal
- British Journal of Anaesthesia
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1016/j.bja.2025.02.035
- Citations
- 2
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- American Thoracic Society
- National Institutes of Health
- National Institute of General Medical Sciences
- NHLBI Division of Intramural Research