Network analysis of extraintestinal manifestations and associated autoimmune disorders in Crohn’s disease and ulcerative colitis
We detect and interactively visualize occurrence, frequency, sequence, and clustering of extraintestinal manifestations (EIM) and associated immune disorders (AID) in 30,334 inflammatory bowel disease (IBD) patients (Crohn's disease (CD) n = 15924, ulcerative colitis (UC) n = 11718, IBD unclassified, IBD-U n = 2692, 52% female, median age 40 years (IQR: 25)) with artificial intelligence (AI). 57% (CD > UC 60% vs. 54%, p < 0.00001) had one or more EIM and/or AID. Mental, musculoskeletal and genitourinary disorders were most frequently associated with IBD: 18% (CD vs. UC 19% vs. 16%, p < 0.00001), 17% (CD vs. UC 20% vs. 15%, p < 0.00001) and 11% (CD vs. UC 13% vs. 9%, p < 0.00001), respectively. AI detected 4 vs. 5 vs. 5 distinct EIM/AID communities with 420 vs. 396 vs. 467 nodes and 11,492 vs. 9116 vs. 16,807 edges (links) in CD vs. UC vs. IBD, respectively. Our newly developed interactive free web app shows previously unknown communities, relationships, and temporal patterns-the diseasome and interactome.
Authors
- Aldo J. Montaño‐Loza (ORCID: https://orcid.org/0000-0002-2511-7980)
- Michael Parkes (ORCID: https://orcid.org/0000-0002-1502-7535)
- Frank Hoentjen (ORCID: https://orcid.org/0000-0001-5314-4452)
- Karen Wong (ORCID: https://orcid.org/0000-0002-5588-2229)
- Daniel Sadowski (ORCID: https://orcid.org/0000-0001-6614-8866)
- Daniel C. Baumgart (ORCID: https://orcid.org/0000-0003-2146-507X)
- Farhad Peerani (ORCID: https://orcid.org/0000-0003-1865-3192)
- Eytan Wine (ORCID: https://orcid.org/0000-0002-3458-4142)
- Sergio Zepeda-Gómez (ORCID: https://orcid.org/0000-0002-5342-016X)
- Randolph Goebel
- Brendan P. Halloran (ORCID: https://orcid.org/0000-0003-0467-1840)
- J. Ross Mitchell
- Tian X. Du
- C.‐H. CHENG
Institutions
- Alberta Health Services (CA)
- University of Alberta (CA)
- Humboldt-Universität zu Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- npj Digital Medicine
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1038/s41746-025-01504-6
- Citations
- 8
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 14.54
Funders
- Canadian Institute for Advanced Research
- Alberta Machine Intelligence Institute
- University of Alberta
- Mitacs
- Alberta Innovates
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada